The TOXINSENS project refers to the design of innovative, versatile and reusable biosensors for the rapid, qualitative and quantitative detection and monitoring of lipopolysaccharides (LPS-endotoxin derived from Gram-negative bacteria, GNB) in various biological samples, food or water.
In this sense, an average consortium was created taking into account the interdisciplinarity and complexity of the project, which includes the Project Coordinator-ICECHIM holding the intellectual property of the Concept addressed in the proposal, a partner with state-of-the-art facilities for characterization, ie UPB and an IMM-EPI SISTEM SRL Partner, able to test the project prototypes, to absorb the manufacturing know-how and to sell the resulting LPS biosensors.
The project uses the following bioinspired concept: Methodology for preparing sensitive films for LPS-TRL 2. The concept was initially proposed by the Project Leader and was developed within the Group of Advanced Polymer Materials and Polymer Recycling from ICECHIM on the project TE123 / 2018 BACTERIOSENS.
From this point, TOXINSENS first aims to update this concept by adding electro-active nanoparticles to the precursor solution for film production. In this way, an electro-active hybrid paste will be generated and used to print LPS-sensitive hybrid films directly on ceramic electrodes (TRL 3). Next, the obtained Hybrid Printed Electrodes will be tested in relevant laboratory environments for LPS recognition, and the innovative technologies will thus be validated (TRL 4).
The specific results of the project will lead to the achievement of several indicators during the implementation of the project (at least 3 publications, 3 papers at prestigious symposia or congresses and 1 patent application), as well as after the end of the project (roadmaps for research and development, data performance, transferable knowledge).
The specific results of the project will lead to the achievement of several indicators during its implementation (at least 3 publications, 3 papers at prestigious symposia or congresses and 1 patent application), as well as after the end of the project (roadmaps for research and development, data performance, transferable knowledge).
For this project, our partners are
Politechnic University of Bucharest Romania
ICECHIM Bucharest Romania (coordinator)
(1.1.1) Study with regards to the necessary specifications for preparing the precursory electroactive paste (viscosity and thermic stability), as well as establishing a commercial reference.
(1.3.2) Communication and results dissemination activities.
(2.1.1) Printing films based on electroactive nanoparticles through 3D technique on plastic or ceramic media.
(2.3.1) Film printing based on electroactive nanoparticles through 3D technique on electrodes.
(2.5.2) Communication and intellectual property protection activities.